Single IRB

 

The NIH Single IRB review requirement  establishes the expectation that a single IRB of record will be used in the ethical review of non-exempt human subjects research protocols funded by the NIH that are carried out at more than one site in the US.


This requirement is effective for all competing grant applications (new, renewal, revision or resubmission) with receipt dates on or after January 25, 2018.
This applies to all domestic sites of NIH-funded, multi-site studies whether supported through grants, cooperative agreements, contracts or the NIH Intramural Research Program.


If you are participating in a multi-center study that requires the use of a Single IRB or have questions about the reliance process, please email irbreliance@bsd.uchicago.edu

Resources Available:

GUIDANCE:

Instructions-

UChicago Relying Upon an External IRB
UChicago Serving as the IRB of Record

Frequently Asked Questions

Suggested Language for Inclusion in NIH Grant Applications
University of Chicago – Language to be included in grant if University of Chicago will serve as reviewing IRB

SMART IRB – Language to be utilized if the SMART IRB agreement will be used for relying upon another site to serve as the IRB of record.

FORMS/AUTHORIZATION Agreements:

IRB Authorization Agreement

Individual Investigator Agreement

Local Site Context Form